Abstract. Although alcohol drinking is considered as an important risk factor for esophageal cancer, the magnitude of the association might be. The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South. Prospective data on environmental exposures, especially with respect to alcohol, tobacco and diet, in relation to the risk of esophageal cancer in high risk.
Previous studies suggested that long-term alcohol consumption may induce increased cell proliferation in the oral and esophageal mucosa of rats 93 As a more direct model for reflecting the effect of salivary acetaldehyde, rats that drank water with an increased concentration of acetaldehyde showed hyperplasia and hyperproliferation in the epithelia of their upper gastrointestinal tract Oral microbes and prolonged ethanol use are two major factors in the generation of salivary acetaldehyde.
This hypothesis has been previously demonstrated in vivo by Homann et al Yokoyama et al 97 showed that following 3 weeks of abstinence, the microorganism count and salivary acetaldehyde production decreased in alcoholics.
Does alcohol cause cancer?
These results indicate a certain mutual effect between ethanol and oral microorganisms. Chronic alcohol consumption may increase bacterial concentrations through affecting salivary gland morphology and decreasing salivary flow 98 As another promoter of microbial acetaldehyde production, tobacco smoking may exhibit a strong association with increased salivary acetaldehyde during alcohol drinking. Smokers that smoke while drinking have 7-fold increased salivary acetaldehyde levels compared with non-smokers With the exception of the direct contribution of acetaldehyde by tobacco smoke, the alteration of oral microorganisms by smoking is also a major source of the increased concentration of salivary acetaldehyde As previously reported, increased yeast infections and conversions from Gram-negative to Gram-positive bacteria has been demonstrated in smokers 99, However, oral bacteria may activate the nitrosamines from tobacco smoking to carcinogenic adducts by forming hydroxylated products — This phenomenon may due to the increased ADH activity, which has been confirmed in Streptococcus gordonii VNeisseria and Streptococcus salivariusthe prevalence of aerobic Gram-positive bacteria and yeast are important in acetaldehyde productiondue to their increased ADH activity.Link Found Between Hot Tea And Esophageal Cancer
Other species, including hemolytic Streptococcus viridans var. Yeasts such as Candida albicans were indicated to have great capacity to produce carcinogenic acetaldehyde Folate deficiency In previous studies, people ingesting a greater quantity and variety of fresh vegetable and fruits were less likely to develop esophageal cancer — Among numerous anticarcinogenic nutrients contained in plant foods, folate intake has been widely demonstrated to be closely associated with cancer of the brain, lung, esophagus, pancreas, colorectum, breast, cervix and breast in previous epidemiological studies Three meta-analyses involving worldwide case-control studies conducted between and reached a consensus that folate intake may effectively protect individuals from ESCC and EAC, with a pooled OR and relative risk RR between 0.
One hypothesis proposed that folate intake was not linearly associated with cancer risk, with a protective effect only in moderate folate intake but no protection or even tumor promotion in low or excessive ingestion People with this condition also develop small growths papillomas in the esophagus and have a very high risk of getting squamous cell cancer of the esophagus.
People with tylosis need to be watched closely to try to find esophageal cancer early. Often this requires regular monitoring with an upper endoscopy described in Tests for Esophagus cancer.
Plummer-Vinson syndrome People with this rare syndrome also called Paterson-Kelly syndrome have webs in the upper part of the esophagus, typically along with anemia low red blood cell counts due to low iron levels, tongue irritation glossitisbrittle fingernails, and sometimes a large thyroid gland or spleen.
A web is a thin membrane extending out from the inner lining of the esophagus that causes an area of narrowing. Most esophageal webs do not cause any problems, but larger ones can cause food to get stuck in the esophagus, which can lead to problems swallowing and chronic irritation in that area from the trapped food.
About 1 in 10 people with this syndrome eventually develop squamous cell cancer of the esophagus or cancer in the lower part of the throat hypopharynx. Workplace exposures Exposure to chemical fumes in certain workplaces may lead to an increased risk of esophageal cancer. For example, exposure to some of the solvents used for dry cleaning might lead to a greater risk of esophageal cancer.
Some studies have found that dry cleaning workers may have a higher rate of esophageal cancer, but not all studies have found this link. Injury to the esophagus Lye is a chemical found in strong industrial and household cleaners such as drain cleaners.
Lye is a corrosive agent that can burn and destroy cells. Accidentally drinking from a lye-based cleaner bottle can cause a severe chemical burn in the esophagus. As the injury heals, the scar tissue can cause an area of the esophagus to become very narrow called a stricture.
Esophageal Cancer Risk Factors
People with these strictures have an increased risk of squamous cell esophageal cancer, which often occurs many years even decades later. History of certain other cancers People who have had certain other cancers, such as lung cancer, mouth cancer, and throat cancer have a high risk of getting squamous cell carcinoma of the esophagus as well.
This may be because these cancers can also be caused by smoking. They are called papilloma viruses because some of them cause a type of growth called a papilloma or wart. Infection with certain types of HPV is linked to a number of cancers, including throat cancer, anal cancer, and cervical cancer.
Signs of HPV infection have been found in up to one-third of esophagus cancers from patients in parts of Asia and South Africa.
Alcohol and Esophageal Cancer
Yes, cancer risk starts to increase at small amounts, so the more you can cut down the more you can reduce your risk. Sticking within the government guidelines is a good place to start. Drinking alcohol causes 11, cases of cancer a year in the UK.
Cutting back has lots of benefits other than reducing your cancer risk- including reducing the risk of accidents, high blood pressure and liver disease. Is binge drinking worse for me?
Alcohol and Esophageal Cancer | Everyday Health
Not when it comes to cancer risk. Research shows drinking alcohol increases the risk of cancer whether you drink it all in one go or spread it throughout the week. Scroll down to find out more about the science behind how alcohol can cause damage. Are there any health benefits of drinking alcohol?